The Establishment of Performance Verification Procedures for Fourier Transform Infrared Spectrometers
DOI:
https://doi.org/10.21423/JRS.REGSCI.3117Keywords:
Spectrometer, Infrared spectroscopy, Infrared microscope, Performance verification procedures, Standard operating proceduresAbstract
An integral part of any laboratory Quality Management System (QMS) is the ability to verify an analytical instrument0s performance prior to analyzing ocial samples. Performance verification procedures provide the instrument user the means to assess whether a system is functioning properly. They are a routine predetermined set of tests and acceptance criteria that can be provided by the instrument manufacturer and/or established by the laboratory itself. Performance verification procedures that have been established for a Fourier transform infrared (FT-IR) microscope system outfitted with a macro sampling accessory allow the user to determine the daily and/or annual functionality of the instrument. Specifications were established for the IR microscope operating in transmission, reflection/absorption (R/A) and attenuated total reflection (ATR) sampling modes. The specifications for the macro sampling accessory were established for transmission and ATR sampling modes only. The acceptance criterion for each performance verification specification was calculated from a series of measurements made using each accessory and sampling mode. The performance verification procedures, as well as their associated specification and acceptance criteria described in this study, are general enough that they can be applied to FT-IR instruments from dierent manufacturers.
References
ASTM International Annual Book of Standards. Section 3 Metals. Tests and Analytical Procedures. Volume 3.06. E1421-99 Standard practice for Describing and Measuring Performance of Fourier Transform Mid-Infrared (FT-MIR) Spectrometers.
European Pharmacopoeia 5.0. Section 2.2.24. Absorption Spectrophotometry. Infrared.
SOP E154: Performance Verification and Preventative Maintenance Procedures for the Nicolet iN10 Fourier Transform Infrared (FT-IR) Microscope and iZ10 AEM Macro FT-IR Spectrometer. 2011; U.S. Food and Drug Administration Forensic Chemistry Center.
SOP E079: Performance Verification, Preventative Maintenance and Data Backup Procedures for the SensIR TravelIR Fourier Transform Infrared (FT-IR) Spectrometer System. 2008; U.S. Food and Drug Administration Forensic Chemistry Center.
SOP E096: Performance Verification, Preventative Maintenance and Data Backup Procedures for the combination JY LabRam IR Raman/Fourier Transform Infrared (FT-IR) Spectrometer System. 2010; U.S. Food and Drug Administration Forensic Chemistry Center.
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